Leukemia inhibitory factor and oncostatin M stimulate collagenase-3 expression in osteoblasts.

IL-6, Leukemia Inhibitory Factor, and Oncostatin M Stimulate Bone Resorption and Regulate the Expression of Receptor Activator of NF- B Ligand, Osteoprotegerin, and Receptor Activator of NF- B in Mouse Calvariae

Calvariae B in Mouse κ and Receptor Activator of NF - B Ligand , Osteoprotegerin , κ Activator of NF - Regulate the Expression of Receptor Oncostatin M Stimulate Bone Resorption and IL - 6 , Leukemia Inhibitory

GP130 cytokines and bone remodelling in health and disease.

Cytokines that bind to and signal through the gp130 co-receptor subunit include interleukin (IL)-6, IL-11, oncostatin M (OSM), leukemia inhibitory factor (LIF), cardiotrophin-1 (CT-1), and ciliary neutrophic factor (CNTF). Apart from contributing to inflammation, gp130 signalling cytokines also function in the maintenance of bone homeostasis. Expression of each of these cytokines and their liga...

Soluble Mediators in Posttraumatic Wrist and Primary Knee Osteoarthritis

Background:  New discoveries about the pathophysiology changed the concept that all forms of osteoarthritis are alike; this lead to the delineation of different phenotypes such as age, trauma or obese related forms. We aim to compare soluble mediator profiles in primary knee and posttraumatic wrist osteoarthritis. Based on the general faster progression rate of wrist osteoarthritis, we hypothes...

Ciliary neurotrophic factor maintains the pluripotentiality of embryonic stem cells.

Ciliary neurotrophic factor was discovered based on its ability to support the survival of ciliary neurons, and is now known to act on a variety of neuronal and glial populations. Two distant relatives of ciliary neurotrophic factor, leukemia inhibitory factor and oncostatin M, mimic ciliary neurotrophic factor with respect to its actions on cells of the nervous system. In contrast to ciliary n...